Vogels Pathways and Memory Networks Inhibitory Plasticity
نویسنده
چکیده
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): January 4, 2012 www.sciencemag.org (this infomation is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/334/6062/1569.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2011/11/10/science.1211095.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/334/6062/1569.full.html#related found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/content/334/6062/1569.full.html#ref-list-1 , 13 of which can be accessed free: cites 47 articles This article http://www.sciencemag.org/content/334/6062/1569.full.html#related-urls 1 articles hosted by HighWire Press; see: cited by This article has been
منابع مشابه
Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm
Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...
متن کاملInhibitory plasticity balances excitation and inhibition in sensory processing and Hebbian assemblies
Cortical neurons receive balanced excitatory and inhibitory membrane currents. Here, we show that such a balance can be established and maintained in an experiencedependent manner by synaptic plasticity at inhibitory synapses. The mechanism we put forward provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interac...
متن کاملSynaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity
Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression-pre- or postsynaptic-is highly variable. Here we introduce a theoretical framework in which long-term plasticity performs an optimization of the postsynaptic response statistics toward a given mean with minimal variance. Consequently, the state of the synapse...
متن کاملInhibitory synaptic plasticity: spike timing-dependence and putative network function
While the plasticity of excitatory synaptic connections in the brain has been widely studied, the plasticity of inhibitory connections is much less understood. Here, we present recent experimental and theoretical findings concerning the rules of spike timing-dependent inhibitory plasticity and their putative network function. This is a summary of a workshop at the COSYNE conference 2012.
متن کاملPrediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity
Synaptic plasticity, neuronal activity-dependent sustained alteration of the efficacy of synaptic transmission, underlies learning and memory. Activation of positive-feedback signaling pathways by an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) has been implicated in synaptic plasticity. However, the mechanism that determines the [Ca(2+)](i) threshold for inducing synaptic plast...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012